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452 Endothelial cells exhibit enhanced NO production and concurrent suppression of endothelin formation, resulting in vascular smooth muscle relaxation and vasodilation mediated by the endothelium (e.g., GLP-1, exenatide, and liraglutide)

Radioimmunoassay provides key turning point One of the key challenges to finding incretin was researchers had no accurate way of measuring insulin and differentiating it from other substances that lowered blood glucose

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