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Persistent constipation, significant abdominal swelling, severe pain, or vomiting should be evaluated rather than treated as routine constipation

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The Gler paper provides a mechanistic substrate for those observations

If it is cloudy or you see particles floating around inside, you should not use it, and you should follow the instructions and protocol previously provided by your doctor if this were to occur

doi: 10.1038/mi.2011.30 45 Pinero-LambeaCBodelonGFernandez-PerianezRCuestaAMAlvarez-VallinaLFernandezLA