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Semaglutide typically produces mild to moderate nausea lasting 26 weeks, with the majority of patients reporting symptom resolution by week 8

Dietary approaches should prioritise: Adequate fibre intake from diverse plant sources to support regular bowel movements (NHS recommends 30g daily) Balanced macronutrients including sufficient protein to support metabolic function Probiotic and prebiotic foods such as yoghurt, kefir, sauerkraut, and foods rich in inulin (onions, garlic, bananas) to support gut microbiome health

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If nausea or gastrointestinal symptoms occur, they are generally attributable to semaglutide's effects on gastric motility rather than a metformin-semaglutide interaction

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