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Labs typically incorporate standard safety procedures, including PPE, proper sharps handling when needles are used in animal studies, and clearly labeled storage

Weekly Schedule Example Option A (standard): 1 mL once weekly 10 doses (10 weeks) Option B (enhanced): 1 mL twice weekly 10 doses (5 weeks) Option C (light): 0.5 mL once weekly 20 doses (20 weeks) 4

Realistic expectation is improvement of small magnitude

To evaluate the general applicability of this approach, we generated additional analogs using antibodies targeting other tumor-associated antigens