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It may support skin brightening, improve complexion, and reduce the appearance of dark spots

M23-0724 10.7326/M23-0724 (2023)

3436 Another meta-analysis of 49 randomized controlled trials found that thiazolidinediones (especially pioglitazone [Actos]) improved steatosis and inflammation but were associated with a weight increase of 4.5 to 11 lb (2 to 5 kg) in 66% to 75% of patients and edema in 4% to 10% of patients

They require coordinated signaling between inflammation resolution, angiogenesis, cellular migration, collagen remodeling, and tissue organization

Yang, J., Ueharu, H

They also found that products that were advertised as containing 10 mg of Melanotan II actually had varied amounts from 4.3 to 8.84 mg [Breindahl T, Evans-Brown M, Hindersson P et al