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Frequently asked questions How does a GLP-1 change your water consumption

15 Although the primary function of GLP-1 is to serve as an anorexigenic (appetite-reducing) and incretin hormone, as well as a mediator of the ileal brake through inhibition of upper gastrointestinal function to prevent malabsorption and postprandial metabolic disturbances, the influence of GLP-1 on colon function was evaluated by a limited number of studies

These typically occur in 20-40% of patients and include: Nausea (most common, especially during dose increases) Vomiting Diarrhea Stomach pain Decreased appetite Constipation These side effects usually improve over time as your body adjusts to the medication

The STEP 1 extension found that the cardiometabolic improvements seen during treatment including blood sugar, blood pressure and cholesterol largely reverted toward baseline within a year of stopping

Combined Efficacy: If the theoretical benefits of targeting mitochondrial function alongside incretin agonism would indeed translate into superior metabolic outcomes compared to using either compound alone

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