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NRF2 -HO-1 pathway Nuclear factor erythroid 2related factor 2 (NRF2) is a master regulator of endogenous antioxidant defenses and plays a pivotal role in maintaining iron homeostasis [112]

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Hantikainen, E.M

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The pooled AUC was 0.839 in internal validation sets and a nearly identical 0.830 in external validation sets, indicating strong generalizability across independent patient populations