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doi:10.3389/fcell.2020.00565 16

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it is a measurable, biochemical reality rooted in disrupted cellular energy pathways

And theres data that supports that

Beyond their established role in T2D, GLP-1RAs are under investigation for potential therapeutic applications in additional clinical domains: non-alcoholic fatty liver disease (NAFLD) [22], neurodegenerative conditions [23], and addiction reduction(including smoking, alcohol use disorder, and cocaine use disorder, putatively via mechanisms analogous to those underlying appetite suppression) [23]

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