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Analysis: The peptide problem: Hype is outrunning the evidence With flimsy or no evidence that using unauthorized peptide drugs is effective in humans, buying the online and self-injecting is high-risk, uncontrolled human self-experimentation, writes Stuart Phillips

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While this partial reduction in cholesterol levels appears beneficial for beta cell GLP-1R function, we previously observed that a much more drastic cholesterol extraction using MCD leads to the opposite effect, inhibiting agonist-induced GLP-1R cAMP responses (25), a result that we hypothesise is linked to the profound disruption of plasma membrane architecture caused by MCD (47)

Meyer AJ, May MJ, Fricker M (2001)

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Endogenous GLP-1 has a short half-life since it is in 1-2 minutes degraded by the enzyme dipeptidyl peptidase-4 (DPP-4)