discovered that lycopene significantly decreased the incidence of AOM-induced ACF, the earliest precursor of CRC, by inhibiting of COX-2 and iNOS, which were overexpressed in the process of colorectal carcinogenesis, thereby preventing the development of CRC (49)
Because it inhibits the proliferation of Treg cells, leptin, a pro-inflammatory adipocytokine, is unusually increased in SLE patients and speeds up the course of lupus nephritis (232, 233)
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