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Managing Side Effects of GLP-1 Medication From nausea to fatigue, side effects can derail progress

A meta-analysis incorporating data from ten tirzepatide studies and involving over 6,800 participants found that tirzepatide at 15mg/weekly resulted in a 10% discontinuation rate due to adverse effects

Use of GLP-1 Drugs to Treat Overweight or Obesity Increased 587 Percent from 2019 to 2024, According to New FAIR Health Study

Skin Appendage Disorders

All of these overlapping factors, caused by GLP-1s and their side effects, can make it a little difficult to say whether the fatigue which patients can feel is directly due to the medication or perhaps just an effect of the changes the body is undergoing as it adapts to this change in food intake and metabolism

Among patients with pre-existing substance use disorder, GLP-1s were tied to fewer hospitalizations, overdoses and deaths related to substance use