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Participants were divided evenly into two groups of 54 people

Radiofrequency microneedle was reported as an effective treatment for refractory melasma, although no large randomized controlled studies have been performed [115,116,117]

Mitochondrial and nuclear mutations leading to a disruption of mitochondrial function are expected to be harmful in the context of immunity, and indeed, the evidence from systemic mitochondrial disorders suggests that such disruptions lead to immunodeficiency (reviewed in [14])

4c,d) and for the Chinese subpopulation for both estimands (Fig

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A 50% reduction in deaths is especially striking, even though the result still needs confirmation in stronger trial settings