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Due to the failure of interventional trials with small antioxidants, more study is needed to investigate disease-specific ROS having therapeutic importance for the future development of prophylactic measure

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Because of this low aqueous solubility, one might imagine that intranasal microparticle delivery would increase the amount delivered

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This increased permeability allows lipopolysaccharides (LPS), food antigens, and microbial byproducts (PAMPs) to translocate into circulation, triggering systemic immune activation and placing further burden on mast cells 18