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In the retatrutide trials, the ratio of fat loss to lean loss was favorable compared to caloric restriction alone, where lean mass can represent 25-35% of total weight lost

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They include: Reaction at injection site Digestive effects (like nausea, vomiting, diarrhea, or constipation) Dizziness Fatigue Hair loss Change in taste Some serious side effects may occur in patients taking either of these drugs