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Acute striatal necrosis can be divided into three stages [70].The first stage is cytotoxic edema in the basal ganglia, cerebral ischemia, and increased blood volume in the gray matter, which occurs within 24 h after motor deficits, and cranial MRI shows increased signal intensity on T2-weighted imaging of the shell nucleus and caudate nucleus [71], along with diffusion limitation [72]

Nonetheless, experts encourage erring on the side of safety and initiating research studies at a lower dose of about 1mg/daily for up to 10 days

PMID: 38673885

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A small molecule activator of SIRT3 promotes deacetylation and activation of manganese superoxide dismutase

Single-mechanism products are not necessarily inferior