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The evidence base was dominated by preclinical animal and mechanistic investigations, while human clinical outcome data were limited and largely observational

Maximum weight loss is often not the goal, says Dr

In severe impairment or if labs are changing, prescribers may pause or hold at a lower step and review more frequently

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The treatments were well tolerated: the incidence of adverse events was similar between groups (73-90%), and most events were gastrointestinal in nature

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