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5 Referral of the patient to a nephrologist is important, as complications such as volume overload, anaemia, electrolyte imbalances and CKD-related mineral and bone disorders can become prominent management issues when the eGFR declines to below the cut-off

The gastrointestinal effects typically emerge within the first few weeks of treatment and may evolve as the body adapts to the medication

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Not recommended for children, adolescents, pregnant and lactating women

Injected once weekly, it has shown an average of 21% weight loss over 72 weeks when combined with lifestyle changes

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