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Tesofensine (2 mg/kg, subcutaneously) and Clozapine-N-Oxide (CNO, 3 mg/kg, intraperitoneally), both drugs or vehicle (DMSO or saline) were administered at 18:30 (30 minutes before the dark cycle begins)

Finally, in vitro work has looked at cellular signaling downstream of 3-AR engagement, providing mechanistic support for the lipolysis-without-hyperglycemia profile that investigators consistently observe

This clean safety profile is what distinguishes this stack from other combination approaches that carry interaction risks

The combination of AOD9604 with HA was more effective than either treatment alone, suggesting a synergistic interaction

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