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Considerations Before Starting Semaglutide: Before beginning treatment with semaglutide, patients should discuss their full medical history with their weight loss provider

When you add semaglutidewhich already slows digestionyou create a situation where eating high-fat foods becomes more likely to trigger bloating, cramping, or diarrhea

Lower Side Effects Nausea and GI symptoms are typically minimal at micro-dose levels

GHK-Cu lowers NFkB, TNF-alpha, and Interleukin 6, the cytokines that trigger the inflammatory response

Contraception becomes more important if pregnancy isn't desired

Despite the longer follow-up in STEP 5 (104 weeks versus 68 weeks in the other STEP trials), STEP 5 was again not designed or powered to assess the impact of semaglutide on the development of weight-related comorbidities such as cardiovascular disease