Hypoglycemia: A potential concern in diabetes management, yet it is typically mild with both treatments and can be effectively managed
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Diclofenac sodium, a commonly prescribed nonsteroidal anti-inflammatory drug (NSAID), depletes GSH through hepatic metabolic byproducts, causing oxidative damage
[DOI] [PMC free article] [PubMed] [Google Scholar] 194.Lynch D.R., Chin M.P., Delatycki M.B., Subramony S.H., Corti M., Hoyle J.C., Boesch S., Nachbauer W., Mariotti C., Mathews K.D., et al
5 , 42, 43, 44 In SCORED, which included patients with CKD with eGFR 25 to 60 ml/min per 1.73 m 2 , a secondary kidney end point was not significantly different between sotagliflozin and placebo (HR 0.71, 95% CI 0.461.08), although the trial was terminated early and likely not of a sufficient duration to detect these differences in composite end points