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Simultaneously, Akt phosphorylates the FOXO family of transcription factors (FOXO1, FOXO3, FOXO4), sequestering them in the cytoplasm and preventing them from transcribing the atrogenes MuRF1 and atrogin-1/MAFbx that drive ubiquitin-proteasome-mediated muscle protein breakdown

doi: 10.1016/J.SCR.2018.06.013 230 KahramanSDiriceEBasileGDiegisserDAlamJJohanssonBBet al