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Acknowledgements This work was supported by Associao Fundo de Incentivo Pesquisa and grants from Fundao de Amparo Pesquisa do Estado de So Paulo (FAPESP, recipient MLA: 2020/13467-8), and Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq, recipient: MLA and ST)

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Symptoms like sweating, shakiness, hunger, dizziness, or confusion need prompt attention

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As a GIP agonist, VK2735 increases insulin and insulin sensitivity, increases glucagon, and decreases food intake

Therefore, we could not definitively assess effects on endpoints recommended by the FDA as appropriate for late-stage studies of NASH therapeutics, namely improvements in histological evidence of fibrosis, or inflammation, or both