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Clinical trials have not reported any serious reactions or toxicities [42]

Liraglutide 3.0 mg reduced BMI by 4.3% over 56 weeks in adolescents with obesity, while placebo reduced BMI by 0.3% in the long term [115]

Additionally, individuals should be aware that: Retatrutide is not licensed in the UK, meaning its full risk profile is still being established Testosterone is a controlled drug in the UK under the Misuse of Drugs Act 1971 when obtained without a valid prescription [11] [12] Any combination therapy should be documented, monitored, and reviewed regularly by a specialist Current MHRA and Clinical Guidance on Combining These Drugs Neither the MHRA nor NICE has issued specific guidance on combining retatrutide and testosterone

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