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In adults with obesity or overweight and knee osteoarthritis, retatrutide at 12 mg produced 23.7% body weight loss (an average of 60 pounds) compared to 4.6% with placebo over a full treatment period

It remains an experimental compound, and its long-term safety profile is not yet fully established

If weight loss plateaus for more than three to four weeks at therapeutic dose, reassess dietary intake, exercise programming, sleep quality, and stress management before attributing the plateau to the medication alone

Important Prior Authorization Tip The prior authorization must include a diabetes diagnosis code

Preparing Financially Retatrutide will likely cost $1,200$1,500/month at list price

Whilst fatigue during retatrutide treatment is often self-limiting, there are several evidence-informed strategies that may help reduce its impact on daily life