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In addition, we also observed lower expression of BAX and caspase 3 and higher expression of Bcl-2 in hyperplastic prostate tissues compared with normal prostate tissues, which showed that with the down-regulation of GPX3, the apoptosis level of hyperplastic prostate was inhibited at the tissue level

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The first being our selection of animals slated for euthanasia for the study, which resulted in our use of several sub-strains of mice (all on a C57BL/6 background), and limited our ability to control early life experiences

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