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Strict payer requirements and limited coverage can delay or restrict therapy uptake, particularly in emerging markets

Going barefoot on hard surfaces, wearing flat shoes without support, or spending extended time in worn-out footwear can undermine healing progress even with peptide therapy

Periodically monitor blood chemistries, vital signs, plasma carnitine concentrations, and overall clinical condition

However, the plasma concentration achieved determines how much NNMT inhibition occurs in target tissues

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