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pubchem.ncbi.nlm.nih.gov

Associated with elevated NAD+ levels and SIRT1 activation in preclinical studies

Both pathways affect weight, metabolic rate, and cardiovascular risk markers, creating potential synergy but also requiring coordinated monitoring

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however, the strength of causal evidence varies across different resistance models.In BRAF inhibitor resistance, PHGDH knockdown reverses resistance, and exogenous serine supplementation rescues the resistant phenotype