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MOTS-c is prohibited by WADA under category S4: Hormone and Metabolic Modulators

Understanding which category you fall into requires looking at the evidence, your personal history, and your metabolic response

How they work: Estrogen creams and suppositories are inserted into the vagina several times per week, and work similarly to vaginal rings, releasing estrogen locally to the vulva and vagina

No claims are made regarding biological activity, safety, efficacy, or medical benefit

However, it has poor water solubility and bioavailability, which can limit its effectiveness [16]