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A 50% reduction in tumor volume compared with free anti-CTLA-4 indicates the potential of peptide-based nanoparticles to improve the clinical standard [140, 141]

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In contrast, after the addition of SB431542, a TGF signalling inhibitor, to the high-glucose medium, -SMA expression in PSCs decreased to a nearly undetectable level

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Injection Site Reactions More common with IGF-1 DES , which is injected directly into the muscle: Localized redness or swelling Muscle soreness Temporary inflammation These reactions usually resolve within a day