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We treated 10- to 12-week-old male sAC / mice with intrajugular 3.6 mol/kg GLP-1(2836) versus the scrambled control 30 minutes prior to standard open-chest IRI involving a 45-minute LAD occlusion

Crucially, it was discovered that these systemic effects were linked to elevated expression of BCAA catabolic genes in mice's thermogenic BAT

Also GLP1RAs have been found to decrease epicardial fat, which may help explain their potential in lowering the risk of atherosclerosis

Why GLP-1 Side Effects Happen GLP-1-based medications affect appetite signaling, satiety, digestion, and how food moves through the stomach and intestines

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They work by imitating glucagon-like peptide-1 (GLP-1), a growth hormone that triggers insulin release, reduces blood sugar levels, slows the passage of food along the intestinal tract and stimulates parts of the brain that control craving and satiety