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doi: 10.1172/JCI99169 80 ZarkovicKJakovcevicAZarkovicN

Their interpretation, however, is inherently integrative and iterative: each datasetgenomic variants, biochemical abnormalities, polygenic modulation, and microbiome-derived pathwaysrefines the others as new information becomes available, allowing the multidisciplinary team to recalibrate the emerging clinical model

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