It enhances insulin secretion, suppresses glucagon release, and slows digestion to promote better glycemic control
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IGF-1 DES: Enhanced IGF-1R Affinity The removal of Gly-Pro-Glu from the N-terminus of IGF-1 DES actually increases intrinsic affinity for the IGF-1 receptor (IGF-1R) compared to native IGF-1
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New England Journal of Medicine , 373(1), 1122