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Moreover, the complex pathogenesis of PD makes it a suitable target for GLP-1RAs, which modulate numerous intracellular signaling pathways, as demonstrated by in vitro and in vivo studies

As in the previously mentioned study there was no difference between GLP-1 receptor agonists and SGLT2 inhibitors in reducing the risk of MACE, but when compared to DPP-4 inhibitors SGLT2 inhibitors significantly reduced cardiovascular and total death

AWARD-3 showed dulaglutide to be superior to metformin in patients with early type 2 diabetes

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