Weight Regain and Cardiometabolic Effects After Withdrawal of Semaglutide: The STEP 1 Trial Extension Diabetes, Obesity and Metabolism 24(8) 2022PMID: 35441470 PubMed 4 Drucker DJ Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1 Cell Metabolism 27(4) 2018PMID: 29617641 PubMed 5 van Bloemendaal L, IJzerman RG, ten Kulve JS, et al
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Bruzzese L, Rostain J-C, Ne L, Condo J, Mottola G, Adjriou N, Mercier L, Berge-Lefranc J-L, Fromonot J, Kipson N, Lucciano M, Durand-Gorde J-M, Jammes Y, Guieu R, Ruf J, Fenouillet E
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The clinical data does not show tolerance development in the way that some other medications lose effectiveness over time
These results show that in the presence of AA, there is a significant reduction in DAT function under both oxidizing and non-oxidizing conditions
