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However, the more honest metric is cost per effective dose , and here oral's lower and more variable systemic bioavailability complicates the picture: if a larger oral dose is needed to achieve a comparable systemic effect, the apparent per-milligram savings shrink
Whether that multiple is justified depends entirely on whether the research question requires glucagon receptor engagement or whether the 4.3 percentage point weight loss advantage over tirzepatide (24.2% vs 20.9%) is scientifically meaningful for the study design
