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Umpierrez (Emory University, Atlanta, GA, USA) and Jennifer Wyckoff (University of Michigan, Ann Arbor, MI, USA)

3.3 LRP1 Interacts with Insulin Signaling The LRP1 receptor is mainly activated by APOE, and this receptor plays an important role in regulating insulin signaling and energy utilization and glucose uptake

In a 26-week Phase 2 obesity trial, cagrilintide 4.5mg produced a mean body-weight reduction of 10.8%, versus 3.0% on placebo and it outperformed liraglutide 3.0mg (10.8% vs 9.0%)[1]