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These findings are further supported by another sub-analysis of SURMOUNT1, which reported a 33.9% (8.2% for placebo) reduction in fat mass and a 10.9% (2.6% for placebo) reduction in lean mass by week 72, with approximately 75% of weight loss attributable to fat mass, consistent across clinically relevant subgroups [68]

This represents a fundamental translational gap that must be acknowledged when interpreting the mechanistic evidence presented in this review

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For a reader weighing MEDVi, the takeaway is narrow: the company received a regulatory communication about how it described its compounded medications, not about the safety of the medications themselves

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These side effects reportedly include pancreatitis, kidney problems, and gastrointestinal issues