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Gpx4 protects mitochondrial ATP generation against oxidative damage

Do not use ibuprofen chronically or repeatedly while on semaglutide without explicit approval from your healthcare team

For maximum effectiveness, retatrutide may surpass tirzepatide but is not yet FDA-approved

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Given that cardiovascular disease is a leading cause of death in MASLD/MASH [1,2] , these parallel cardiometabolic benefits confer additional target-organ protection, further reinforcing the appeal of semaglutide in this high-risk population