Throughout the follow-up period, HbA1C levels remained consistently higher in the GLP-1 RAs group (Figure S1)
The notion that GLP-1 analogues may affect feeding even when they do not enter the brain is supported by studies showing that large molecular size GLP-1 receptor agonists (albumin-conjugated GLP-1 receptor agonists), that cannot cross the blood-brain barrier can inhibit feeding in both humans and mice
Again, this is to ensure the medication is properly absorbed
Besides, GLP-1RAs might be driven by anti-inflammatory mechanisms to inhibit the formation of macrophage foam cells and thus slow down the pathological processes of AS (125, 126)
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When appropriate, they are prescribed only after individualized medical evaluation and filled by a licensed U.S