The rationale for including glucagon receptor agonism is the mechanistically interesting part: glucagon signalling raises hepatic energy expenditure and promotes lipolysis but also raises circulating glucose on its own, so the two incretin arms are there to counterbalance that consequence while the thermogenic effect proceeds
The company designs peptide analogs to enhance biological activity, extend duration of action, and increase stability, thereby providing innovative and improved treatments for various diseases
Jun 2017;139(6):1906-1913 e4
This "dual-action" approach is often helpful for those who haven't seen results with other medications
For patients wondering why progress has slowed, reviewing reasons for not losing weight often reveals correctable issues
Additionally, if the third-party providers of therapies or therapies in development used in combination with our product candidates are unable to produce sufficient quantities for clinical trials or for commercialization of our product candidates, or if the cost of combination therapies are prohibitive, our development and commercialization efforts would be impaired, which would have an adverse effect on our business, financial condition, results of operations and growth prospects
