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Following those promising results, a phase 1 study tested ascending doses (3, 9, 20, 40, 80, and 150 g) of SAR441255 against placebo reported a decrease in both fasting and post prandial blood glucose in the SAR441255 group

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The UVA team found that, in addition to those established effects, the drugs also engage a separate circuit linking the hindbrain to the central amygdala, which is involved in processing emotions, and ultimately to dopamine-producing neurons

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