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These mechanisms collectively trigger and sustain inflammation, atherosclerosis, and organ-specific complications such as retinopathy, nephropathy, neuropathy, metabolic-dysfunction associated steatotic liver disease (MASLD), cardiopathy, and brain disease [5]

Dual GLP-1/GIP Receptor Agonists : While clinical evidence is growing for dual-acting therapies, it is a more recent area of development compared to GLP-1 monotherapy

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Likewise, Buchnera of tribe Macrosiphini encoded SyeB with recognizable sequence homology across species, whereas Buchnera of tribe Aphidini encoded a short protein in the same position, but without sequence similarity to SyeB

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