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Cryo-EM and computational structural work using the published tirzepatide-bound GLP-1R and GIPR structures deposited in the Protein Data Bank for docking, mutagenesis, and structure-activity analysis

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These peptides mimic the spatial conformation of the parent (native) molecules while exhibiting significantly enhanced resistance to enzymatic degradation, thereby enabling prolonged biological activity and reduced immunogenicity

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Check ClinicalTrials.gov for ongoing TRIUMPH trials or extension studies