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For the MMRM analysis, 309 participants who completed Part 1 and initiated Part 2 (the 52-week blinded dose extension phase where all participants received prasinezumab) were included

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Based on published clinical trial data, retatrutide has demonstrated the greatest magnitude of weight reduction (24.2% at 48 weeks), surpassing tirzepatide (22.5% at 72 weeks) and semaglutide (16% at 68 weeks) and in a shorter timeframe

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A personal or family history of Medullary Thyroid Cancer (MTC) or MEN 2 is the key exception