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The IADVL 2017 Position on Skin Lightening Agents takes a careful line on intravenous glutathione: the FDA has not approved it for cosmetic indications, the dermatology evidence base shows modest tyrosinase-inhibition effect with topical pigment control doing most of the visible work, and the off-label cosmetic use sits firmly outside a curative claim

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[DOI] [PubMed] 92.Fatoke-Osobukola E., Ernest K., Carroll M.A., Catapane E.J