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Lysosomal cysteine cathepsins B and L are often overexpressed in aggressive tumors, and upon their transfer to the invadosomes and following secretion to the extracellular space, they can participate in the degradation of the extracellular matrix [46, 48]

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The answer to the first question is that he first performed a preliminary study with a wider range of doses, reported in the same paper

doi: 10.3390/molecules26030752 180 ManikM.SinghR

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