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In Figure 9 , NAPQI formed in SER and/or mitochondria binds to a protein(s) in or associated with complex III of the ETC to allow electrons to combine with O 2 to create O 2 .- , which is directed into the intermembrane space

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A single 1,000 mg IV dose restores circulating levels faster than any oral regimen and avoids the GI side effects that limit high-dose oral vitamin C