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15 found that fentanyl-induced analgesia, decreased tidal volume (Vt) and increased Alveolar-arterial (A-a) gradient (ventilation-perfusion mismatch) 16 , was reduced by a peripherally-restricted -OR antagonist, naloxone methiodide

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In short, the tensions described in this article are inherent in off-label prescribing and dispensing no matter the therapy at issue, and routinely lead to significant enforcement actions against providers

Reported weight change in older adults and presence of frailty

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