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Intervention and supplementation trials yielded inconsistent results

This work was supported with grants by Spanish Ministry of Science and Innovation (PID2020-113813RB-I00 and PID2023-146670OB-C21) and the European Commission NextGenerationEU (Regulation EU 2020/2094), through CSIC's Global Health Platform (PTI Salud Global) and Generalitat de Catalunya (2021-SGR-00504)

Informed consent was obtained and the use of a patient specimen and relevant database was approved by the Human Research Ethics Committee of Tianjin Medical University

It is noteworthy that this superior effectiveness extended to primates (humans and cynomolgus monkeys) and rodent models of obesity and diabetes, such as db/db (diabetic) mice and Zucker diabetic fatty (ZDF) rat

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There were no group differences in terms of laboratory findings, heart-related parameters, and vital signs