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It may not be harmful, but effectiveness is no longer guaranteed

When interpreting results, the authors emphasized that metformin, the comparator, may itself reduce cancer risk, which could partly explain the narrower benefits seen in that arm

Popular GLP-1 Drug Cost Comparison Prices reflect manufacturer self-pay programs as of early 2026 and are subject to change

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As mesolimbic dopaminergic pathways are implicated in motivation, perceived energy, and reward-seeking behavior, underactivation of this pathway, potentially through GLP-1RA administration, has been implicated in psychiatric disorders such as depression [153]